陸昌瑞教授
陸昌瑞，博士、博導(dǎo)、教授、上海高校特聘教授。1983年6月出生。美國科爾蓋特大學(xué)（Colgate University）全額獎(jiǎng)學(xué)金分子生物學(xué)學(xué)士、高等榮譽(yù)（2005年），美國康奈爾大學(xué)（Cornell University）生命科學(xué)研究生院生物化學(xué)、生物物理學(xué)博士（2010年），美國密西根大學(xué)（University of Michigan）醫(yī)學(xué)院博士后（2011年），2012年入職東華大學(xué)。
研究方向：
1、RNA的結(jié)構(gòu)和功能
2、RNA核酸藥物的開發(fā)和質(zhì)檢
榮譽(yù)及獲獎(jiǎng)情況：
上海市高校特聘教授（東方學(xué)者）
近年來承擔(dān)的主要科研項(xiàng)目：
主持國家自然基金委、市科委、衛(wèi)健委的縱向項(xiàng)目和多個(gè)龍頭企業(yè)的橫向項(xiàng)目，總金額千萬余元。
近年來發(fā)表的代表性論著、專利：
論文
1. Capping in mRNA analyzed using Pistol ribozyme and LC-MS. Biochemical and Biophysical Research Communications. 2025.
2. Escherichia coli yybP-ykoY Riboswitch as a Tandem Riboswitch Regulated by Mn2+ and pH. ACS Chemical Biology. 2025.
3. RNA Binding to CCRRM of PABPN1 Induces Conformation Change. Biology. 2025.
4. The LSmAD Domain of Ataxin-2 Modulates the Structure and RNA Binding of Its Preceding LSm Domain. Cells. 2025.
5. Linker-Mediated Inactivation of the SAM-II Domain in the Tandem SAM-II/SAM-V Riboswitch. International Journal of Molecular Sciences. 2024.
6. mRNA Fragmentation Pattern Detected by SHAPE. Current Issues in Molecular Biology. 2024.
7. Bifidobacterium bifidum SAM-VI Riboswitch Conformation Change Requires Peripheral Helix Formation. Biomolecules. 2024.
8. Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine. Antiviral Research. 2023.
9. The second class of tetrahydrofolate (THF-II) riboswitches recognizes the tetrahydrofolic acid ligand via local conformation changes. International Journal of Molecular Sciences. 2022.
10. Intein-mediated recombinant expression of monomeric B22Asp desB30 insulin. BMC biotechnology. 2020.
11.ATP/ADP modulates gp16–pRNA conformational change in the Phi29 DNA packaging motor. Nucleic acids research. 2019.
12.Large-scale in vitro transcription, RNA purification and chemical probing analysis. Cellular Physiology and Biochemistry. 2018.
13.Structure and assembly of the essential RNA ring component of a viral DNA packaging motor. Proceedings of the National Academy of Sciences. 2011.
14.Variable sequences outside the SAM-binding core critically influence the conformational dynamics of the SAM-III/SMK box riboswitch. Journal of molecular biology. 2011.
15.SAM recognition and conformational switching mechanism in the Bacillus subtilis yitJ S box/SAM-I riboswitch. Journal of molecular biology. 2010.
16. Crystal structures of the SAM-III/SMK riboswitch reveal the SAM-dependent translation inhibition mechanism. Nature structural & molecular biology. 2008.
著作
Using tRNA Scaffold to Assist RNACrystallization. RNA Scaffolds: Methods and Protocols, 39-47. 2021.
專利
公布專利：
CN119799865A、CN116768988A、CN116768987A、CN114146229A
多個(gè)RNA藥物相關(guān)專利實(shí)審階段。
主要學(xué)術(shù)兼職：
1.上海市生物化學(xué)與分子生物學(xué)學(xué)會(huì)理事
2.上海市化工學(xué)會(huì)理事
3.美國Phi Beta Kappa榮譽(yù)學(xué)會(huì)
4.美國Tri-Beta生物學(xué)會(huì)
國際交流與合作：
和多個(gè)國際著名高校、醫(yī)療機(jī)構(gòu)保持長期合作關(guān)系。
聯(lián)系電話： 18721991136 E-MAIL：crlu@dhu.edu.cn
